Article
Functional consequence of targeting protein kinase B/Akt to GLUT4 vesicles.
Journal of cell science - 15 Jul 2002
Ducluzeau Pierre-Henri, Fletcher Laura M, Welsh Gavin I, Tavaré Jeremy M
Abstract excerpt
We have investigated the role of protein kinase B (Akt) in the insulin-stimulated translocation of vesicles containing the insulin-responsive isoform of glucose transporter (GLUT4) to the plasma membrane of adipocytes. Previous reports have suggested that protein kinase B can bind to intracellular GLUT4 vesicles in an insulin-dependent manner, but the functional consequence of this translocation is not known. In...
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