Article
Confronting complexity in late-onset Alzheimer disease: application of two-stage analysis approach addressing heterogeneity and epistasis.
Genetic epidemiology - 1 Apr 2008
Thornton-Wells Tricia A, Moore Jason H, Martin Eden R, Pericak-Vance Margaret A, Haines Jonathan L
Abstract excerpt
Common diseases with a genetic basis are likely to have a very complex etiology, in which the mapping between genotype and phenotype is far from straightforward. A new comprehensive statistical and computational strategy for identifying the missing link between genotype and phenotype has been proposed, which emphasizes the need to address heterogeneity in the first stage of any analysis and gene-gene interactions...
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