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Article

Identification and characterization of mutations conferring resistance to an HCV RNA-dependent RNA polymerase inhibitor in vitro.

Antiviral research - 1 Oct 2007

Lu Liangjun, Dekhtyar Tatyana, Masse Sherie, Pithawalla Ron, Krishnan Preethi, He Wenping, Ng Teresa, Koev Gennadiy, Stewart Kent, Larson Dan, Bosse Todd, Wagner Rolf, Pilot-Matias Tami, Mo Hongmei, Molla Akhteruzumman

Abstract excerpt

Compound A-837093, a non-nucleoside HCV RNA-dependent RNA polymerase inhibitor, displayed nanomolar potencies against HCV genotypes 1a and 1b replicons. It also exhibited an excellent metabolic profile and achieved high plasma and liver concentrations in animals. In order to characterize the development of resistance to this anti-HCV agent, HCV subgenomic 1b strain N replicon cells were cultured in the presence...

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Identifiers

PMID: 17561278
DOI: 10.1016/j.antiviral.2007.04.005

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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