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Article

In vitro activity and resistance profile of dasabuvir, a nonnucleoside hepatitis C virus polymerase inhibitor.

Antimicrobial agents and chemotherapy - 1 Mar 2015

Kati Warren, Koev Gennadiy, Irvin Michelle, Beyer Jill, Liu Yaya, Krishnan Preethi, Reisch Thomas, Mondal Rubina, Wagner Rolf, Molla Akhteruzzaman, Maring Clarence, Collins Christine

Abstract excerpt

Dasabuvir (ABT-333) is a nonnucleoside inhibitor of the RNA-dependent RNA polymerase encoded by the hepatitis C virus (HCV) NS5B gene. Dasabuvir inhibited recombinant NS5B polymerases derived from HCV genotype 1a and 1b clinical isolates, with 50% inhibitory concentration (IC50) values between 2....

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Identifiers

PMID: 25534735
DOI: 10.1128/AAC.04619-14
PMCID: PMC4325770

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25534735-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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