Article
Polymorphisms spanning the 0N exon and promoter of the estrogen receptor-beta (ERbeta) gene ESR2 are associated with venous ulceration.
Clinical genetics - 1 Jan 2008
Ashworth J J, Smyth J V, Pendleton N, Horan M, Payton A, Worthington J, Ollier W E, Ashcroft G S
Abstract excerpt
Venous ulcers are characterized by excessive inflammation and raised levels of proinflammatory cytokines. Estrogen has been shown to accelerate the rate of wound healing in elderly subjects by dampening the inflammatory response. The estrogen receptor (ER) proteins, ER-alpha (ERalpha) and ER-beta...
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