Article

Genetic Polymorphisms and Vascular Dysfunction in Lipedema: Implications for a Non-Hormonal Pathophysiological Model

2026-04-29

Abstract excerpt

Lipedema is a chronic, progressive adipose tissue disorder predominantly affecting women and has been widely proposed as an estrogen-dependent condition despite the lack of objective causal evidence. In contrast, increasing data implicate genetic heterogeneity, endothelial dysfunction, and altered vascular permeability as central features of the disease. This review critically reassesses the estrogen-dependence hy...

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Literature Corpus work: 9956caa1-a65e-5bbc-9e35-fe54167517a1
DOI: 10.20944/preprints202604.2085.v1

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