Article
Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.
Genes, chromosomes & cancer - 1 Mar 2008
Linger Rachel, Dudakia Darshna, Huddart Robert, Tucker Kathy, Friedlander Michael, Phillips Kelly-Anne, Hogg David, Jewett Michael A S, Lohynska Radka, Daugaard Gedske, Richard Stéphane, Chompret Agnes, Stoppa-Lyonnet Dominique, Bonaïti-Pellié Catherine, Heidenreich Axel, Albers Peter, Olah Edith, Geczi Lajos, Bodrogi Istvan, Daly Peter A, Guilford Parry, Fosså Sophie D, Heimdal Ketil, Tjulandin Sergei A, Liubchenko Ludmila, Stoll Hans, Weber Walter, Einhorn Lawrence, McMaster Mary, Korde Larissa, Greene Mark H, Nathanson Katherine L, Cortessis Victoria, Easton Douglas F, Bishop D Timothy, Stratton Michael R, Rapley Elizabeth A
Abstract excerpt
A base substitution in the mouse Dnd1 gene resulting in a truncated Dnd protein has been shown to be responsible for germ cell loss and the development of testicular germ cell tumors (TGCT) in the 129 strain of mice. We investigated the human orthologue of this gene in 263 patients (165 with a family history of TGCT and 98 without) and found a rare heterozygous variant, p. Glu86Ala, in a single case. This variant...
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