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Article

Screening for germline DND1 mutations in testicular cancer patients.

Familial cancer - 1 Sept 2010

Sijmons Rolf H, Vos Yvonne J, Herkert Johanna C, Bos Krista K, Lutke Holzik Martijn F, Hoekstra-Weebers Josette E H M, Hofstra Robert M W, Hoekstra Harald J

Abstract excerpt

Although several observations suggest that a strong genetic predisposition to developing testicular germ cell tumors (TGCT) exists, no associated, highly penetrant germline mutations have been identified so far. In the 129/Sv mouse strain, a germline mutation in the DND1 gene has been shown to strongly increase the TGCT risk. We screened 272 men with TGCT (89% sporadic cases, 11% familial) for germline mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 20411342
DOI: 10.1007/s10689-010-9340-y
PMCID: PMC2921500

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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