Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity.

doi:10.1002/humu.21134

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity.

Human mutation - 1 Jan 2010

Tchatchou Sandrine, Riedel Angela, Lyer Stefan, Schmutzhard Julia, Strobel-Freidekind Olga, Gronert-Sum Sabine, Mietag Carola, D'Amato Mauro, Schlehe Bettina, Hemminki Kari, Sutter Christian, Ditsch Nina, Blackburn Anneke, Hill Linda Zhai, Jerry D Joseph, Bugert Peter, Weber Bernhard H F, Niederacher Dieter, Arnold Norbert, Varon-Mateeva Raymonda, Wappenschmidt Barbara, Schmutzler Rita K, Engel Christoph, Meindl Alfons, Bartram Claus R, Mollenhauer Jan, Burwinkel Barbara

Abstract excerpt

According to present estimations, the unfavorable combination of alleles with low penetrance but high prevalence in the population might account for the major part of hereditary breast cancer risk. Deleted in Malignant Brain Tumors 1 (DMBT1) has been proposed as a tumor suppressor for breast cancer and other cancer types. Genomewide mapping in mice further identified Dmbt1 as a potential modulator of breast...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Breast Neoplasms, Male

Share to Calcium-Binding Proteins

Share to Case-Control Studies

Share to DNA-Binding Proteins

Share to Promoter Regions, Genetic

Share to Receptors, Cell Surface

Share to Tumor Suppressor Proteins

Source

Open in PubMed

Identifiers

PMID: 19830809
DOI: 10.1002/humu.21134

Genes

DMBT1
BRCA1

Variants

rs2981745

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of a DMBT1 polymorphism associated with increased breast cancer risk and decreased promoter activity.PMID 19830809Read ↗

Genetic mapping in mice identifies DMBT1 as a candidate modifier of mammary tumors and breast cancer risk.Semantic proximity Read ↗

Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors.Semantic proximity Read ↗

<scp>DMP1β</scp>, a splice isoform of the tumour suppressor <i><scp>DMP1</scp></i> locus, induces proliferation and progression of breast cancerSemantic proximity Read ↗

Carcinogen inducibility in vivo and down-regulation of DMBT1 during breast carcinogenesis.Semantic proximity Read ↗

Rare mutations of the DMBT1 gene in human astrocytic gliomas.Semantic proximity Read ↗

DMBT1 polymorphisms: relationship to malignant glioma tumorigenesis.Semantic proximity Read ↗

The SRCR/SID region of DMBT1 defines a complex multi-allele system representing the major basis for its variability in cancer.Semantic proximity Read ↗

Analysis of ZNF350/ZBRK1 promoter variants and breast cancer susceptibility in non-BRCA1/2 French Canadian breast cancer families.Semantic proximity Read ↗

Association of the BRCA1 promoter polymorphism rs11655505 with the risk of familial breast and/or ovarian cancer.Semantic proximity Read ↗

Molecular characterization of the porcine deleted in malignant brain tumors 1 gene (DMBT1).Semantic proximity Read ↗

Analysis of the DND1 gene in men with sporadic and familial testicular germ cell tumors.Semantic proximity Read ↗

Glutathione-S-transferase M1, T1 and P1 polymorphisms, and breast cancer risk, in BRCA1/2 mutation carriers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.