BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility.

doi:10.1111/j.2047-2927.2014.00230.x

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Article

BRDT gene sequence in human testicular pathologies and the implication of its single nucleotide polymorphism (rs3088232) on fertility.

Andrology - 1 Jul 2014

Barda S, Yogev L, Paz G, Yavetz H, Lehavi O, Hauser R, Doniger T, Breitbart H, Kleiman S E

Abstract excerpt

Bromodomain testis-specific (BRDT) protein is essential for the normal process of spermatogenesis. Mutant mice that expressed truncated BRDT had impaired testicular histology with severely reduced sperm concentration and abnormal sperm morphology, while a model of knockout Brdt mice with no BRDT protein had complete meiotic arrest. A BRDT single nucleotide polymorphism (SNP) (rs3088232) was reported as being...

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PMID: 24865796
DOI: 10.1111/j.2047-2927.2014.00230.x

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BRDT

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