Article
Mutation analysis of DMBT1 in glioblastoma, medulloblastoma and oligodendroglial tumors.
International journal of cancer - 20 May 2003
Pang Jesse Chung-Sean, Dong Zhiqian, Zhang Rong, Liu Yanhui, Zhou Liang-Fu, Chan Bik Wan, Poon Wai Sang, Ng Ho-Keung
Abstract excerpt
DMBT1 has been implicated as a candidate tumor suppressor gene on chromosome 10q for brain, gastrointestinal and lung cancer. Homozygous deletion and lack of expression are 2 known mechanisms for inactivating DMBT1. We evaluated whether somatic mutation, which represents a major inactivation mechanism for most tumor suppressor genes, occurs in the DMBT1 gene. A total of 102 primary brain tumors, consisting of 25...
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