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Article

Effects of introduction of hydrophobic group on ribavirin base on mutation induction and anti-RNA viral activity.

Journal of medicinal chemistry - 10 Jan 2008

Moriyama Kei, Suzuki Tetsuya, Negishi Kazuo, Graci Jason D, Thompson Corinne N, Cameron Craig E, Watanabe Masahiko

Abstract excerpt

One of the possible mechanisms of antiviral action of ribavirin (1-beta- d-ribofuranosyl-1,2,4-triazole-3-carboxamide, 1) is the accumulation of mutations in viral genomic RNA. The ambiguous incorporation of 5'-triphosphate of ribavirin (RTP, 8) by a viral RNA-dependent RNA polymerase (RdRp) is a key step of the mutation induction. We synthesized three ribavirin analogues that possess hydrophobic groups,...

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Identifiers

PMID: 18067241
DOI: 10.1021/jm7009952

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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