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Article

Effects of mutations of the initiation nucleotides on hepatitis C virus RNA replication in the cell.

Journal of virology - 1 Apr 2004

Cai Zhaohui, Liang T Jake, Luo Guangxiang

Abstract excerpt

Replication of nearly all RNA viruses depends on a virus-encoded RNA-dependent RNA polymerase (RdRp). Our earlier work found that purified recombinant hepatitis C virus (HCV) RdRp (NS5B) was able to initiate RNA synthesis de novo by using purine (A and G) but not pyrimidine (C and U) nucleotides (G. Luo et al., J. Virol. 74:851-863, 2000). For most human RNA viruses, the initiation nucleotides of both positive-...

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Share to Virus Replication
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Reverse Transcriptase Polymerase Chain Reaction

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Source

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Identifiers

PMID: 15016884
DOI: 10.1128/jvi.78.7.3633-3643.2004
PMCID: PMC371060

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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