Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance.

Nucleosides, nucleotides & nucleic acids - 1 Jan 2005

Alvarez Karine, Deval Jérôme, Selmi Boulbaba, Barral Karine, Boretto Joelle, Guerreiro Catherine, Mulard Laurence, Sarfati Robert, Canard Bruno

Abstract excerpt

Alpha-boranophosphates suppress RT-mediated resistance when the catalytic rate of incorporation (kpol) of the analogue 5'-triphosphate is responsable for drug resistance, such as in the case of K65R mutant and ddNTPs, and Q151M toward AZTTP and ddNTPs. This suppression is also observed with BH3-d4T and BH3-3TC toward their clinically relevant mutants Q151M and M184V. Moreover, the presence of the borano (BH3-)...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acids
Share to Anti-HIV Agents

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Boron Compounds

Share to Chemistry, Pharmaceutical

Share to Drug Design

Share to HIV Reverse Transcriptase

Share to Oxygen

Share to Phosphates

Source

Identifiers

PMID: 16247962
DOI: 10.1081/NCN-200059951

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Borano-nucleotides: new analogues to circumvent HIV-1 RT-mediated nucleoside drug-resistance.PMID 16247962Read ↗

In vitro suppression of K65R reverse transcriptase-mediated tenofovir- and adefovir-5'-diphosphate resistance conferred by the boranophosphonate derivatives.Semantic proximity Read ↗

The molecular mechanism of multidrug resistance by the Q151M human immunodeficiency virus type 1 reverse transcriptase and its suppression using alpha-boranophosphate nucleotide analogues.Semantic proximity Read ↗

Selective targeting of the HIV-1 reverse transcriptase catalytic complex through interaction with the "primer grip" region by pyrrolobenzoxazepinone non-nucleoside inhibitors correlates with increased activity towards drug-resistant mutants.Semantic proximity Read ↗

Suppression of multidrug-resistant HIV-1 reverse transcriptase primer unblocking activity by alpha-phosphate-modified thymidine analogues.Semantic proximity Read ↗

Mechanism-based Suppression of Dideoxynucleotide Resistance by K65R Human Immunodeficiency Virus Reverse Transcriptase Using an α-Boranophosphate Nucleoside AnalogueSemantic proximity Read ↗

Molecular determinants of multi-nucleoside analogue resistance in HIV-1 reverse transcriptases containing a dipeptide insertion in the fingers subdomain: effect of mutations D67N and T215Y on removal of thymidine nucleotide analogues from blocked DNA primers.Semantic proximity Read ↗

Specific targeting highly conserved residues in the HIV-1 reverse transcriptase primer grip region. Design, synthesis, and biological evaluation of novel, potent, and broad spectrum NNRTIs with antiviral activity.Semantic proximity Read ↗

Methylene bisphosphonates as the inhibitors of HIV RT phosphorolytic activity.Semantic proximity Read ↗

Nucleoside and nucleotide inhibitors of HIV-1 replication.Semantic proximity Read ↗

Modular assembly of purine-like bisphosphonates as inhibitors of HIV-1 reverse transcriptase.Semantic proximity Read ↗

Connection domain mutations N348I and A360V in HIV-1 reverse transcriptase enhance resistance to 3'-azido-3'-deoxythymidine through both RNase H-dependent and -independent mechanisms.Semantic proximity Read ↗

Anti-HIV Drug Discovery and Development: Current Innovations and Future Trends.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.