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Synthesis of 1-beta-D-ribofuranosyl-3-ethynyl-[1,2,4]triazole and its in vitro and in vivo efficacy against Hantavirus.

Antiviral research - 1 Jul 2008

Chung Dong-Hoon, Kumarapperuma Sidath C, Sun Yanjie, Li Qianjun, Chu Yong-Kyu, Arterburn Jeffrey B, Parker William B, Smith Jeffrey, Spik Kristin, Ramanathan Harish N, Schmaljohn Connie S, Jonsson Colleen B

Abstract excerpt

There are no FDA approved drugs for the treatment of hemorrhagic fever with renal syndrome (HFRS), a serious human illnesses caused by hantaviruses. Clinical studies using ribavirin (RBV) to treat HFRS patients suggest that it provides an improved prognosis when given early in the course of disease. Given the unique antiviral activity of RBV and the lack of other lead scaffolds, we prepared a diverse series of...

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Identifiers

PMID: 18394724
DOI: 10.1016/j.antiviral.2008.02.003
PMCID: PMC2692291

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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