Article
Development of modified nucleosides that have supremely high anti-HIV activity and low toxicity and prevent the emergence of resistant HIV mutants.
Proceedings of the Japan Academy. Series B, Physical and biological sciences - 1 Jan 2011
Ohrui Hiroshi
Abstract excerpt
An idea to use 4'-C-substituted-2'-deoxynucleoside derivatives was proposed based on a working hypothesis to solve the problems of existing acquired immune deficiency syndrome chemotherapy (highly active antiretroviral therapy). Subsequent studies have successfully proved the validity of the idea and resulted in the development of 2'-deoxy-4'-C-ethynyl-2-fluoroadenosine and...
Topics
- Animals
- Anti-HIV Agents
- Drug Discovery
- Drug Resistance, Viral
- HIV
- Humans
- Intracellular Space
- Male
- Mice
- Mutation
- Nucleic Acid Synthesis Inhibitors
- Nucleosides
- Reproducibility of Results
- Structure-Activity Relationship