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Article

Small heat shock proteins Hsp27 or αB‐crystallin and the protein components of neurofibrillary tangles: Tau and neurofilaments

5 Dec 2007

Abstract excerpt

The heat-shock proteins (HSPs) Hsp27 and alphaB-crystallin are up-regulated in Alzheimer's disease (AD), but the extent of this and the consequences are still largely unknown. The HSPs are involved in protein degradation and protection against protein aggregation, and they interact with several cytoskeletal components such as microtubules (MT) and neurofilaments (NF). AD pathology includes aggregated proteins...

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PMID: 18061943
DOI: 10.1002/jnr.21589

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