Article
Favourable Prognostic Significance of HER2 Mutations in Canine Pulmonary Adenocarcinoma Following Surgical Resection.
Veterinary and comparative oncology - 1 Mar 2026
Ichimata Masanao, Kagawa Yumiko, Toshima Atsushi, Igase Masaya, Mizuno Takuya
Abstract excerpt
Human epidermal growth factor receptor 2 (HER2) gene mutations have been reported in 5% to 38% of canine pulmonary adenocarcinomas (cPACs), most commonly as V659E mutations in exon 20. However, their prognostic and predictive significance remains unclear. This retrospective, single-centre cohort study investigated the frequency of HER2 mutations in surgically resected cPACs and their association with clinical...
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