Article
Ca2+/calmodulin-based signalling in the regulation of the muscle fibre phenotype and its therapeutic potential via modulation of utrophin A and myostatin expression.
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme - 1 Oct 2007
Michel Robin N, Chin Eva R, Chakkalakal Joe V, Eibl Joe K, Jasmin Bernard J
Abstract excerpt
Ca2+ signalling plays an important role in excitation-contraction coupling and the resultant force output of skeletal muscle. It is also known to play a crucial role in modulating both short- and long-term muscle cellular phenotypic adaptations associated with these events. Ca2+ signalling via the Ca2+/calmodulin (CaM)-dependent phosphatase calcineurin (CnA) and via Ca2+/CaM-dependent kinases, such as CaMKI and...
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