Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Promoter Hypermethylation of the RUNX3 Gene in Esophageal Squamous Cell Carcinoma

1 Jan 2007

Abstract excerpt

Alteration in transforming growth factor-beta (TGF-beta) signaling pathway is one of the main causes of esophageal squamous cell carcinoma (ESCC). The human runt-related transcription factor 3 (RUNX3), an important component of TGF-beta pathway which is located at 1p36, is commonly deleted in a variety of human cancers, including ESCC. Hypermethylation of RUNX3 promoter was frequently found in gastrointestinal...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research
Share to TGF-β signaling in diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 18058463
DOI: 10.1080/07357900701561131

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Promoter Hypermethylation of the RUNX3 Gene in Esophageal Squamous Cell CarcinomaPMID 18058463Read ↗

Association of Promoter Methylation of RUNX3 Gene with the Development of Esophageal Cancer: A Meta AnalysisSemantic proximity Read ↗

Expression of RUNX3 Gene, Methylation Status and Clinicopathological Significance in Breast Cancer and Breast Cancer Cell LinesSemantic proximity Read ↗

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.Semantic proximity Read ↗

Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from IndiaSemantic proximity Read ↗

Allele loss and promoter hypermethylation of VHL, RAR-beta, RASSF1A, and FHIT tumor suppressor genes on chromosome 3p in esophageal squamous cell carcinoma.Semantic proximity Read ↗

Long non‑coding RNA MEG3 suppresses epithelial‑to‑mesenchymal transition by inhibiting the PSAT1‑dependent GSK‑3β/Snail signaling pathway in esophageal squamous cell carcinomaSemantic proximity Read ↗

Promoter hypermethylation and inactivation of O6-methylguanine-DNA methyltransferase in esophageal squamous cell carcinomas and its reactivation in cell linesSemantic proximity Read ↗

Screening of candidate tumor-suppressor genes in 3p21.3 and investigation of the methylation of gene promoters in oral squamous cell carcinoma.Semantic proximity Read ↗

A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.Semantic proximity Read ↗

Hypermethylation of RUNX3 but not WIF1 gene and its association with stage and nodal status of tongue cancersSemantic proximity Read ↗

RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status.Semantic proximity Read ↗

Helicobacter pylori infection is an independent risk factor for Runx3 methylation in gastric cancerSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.