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Article

Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.

Biochemical and biophysical research communications - 30 Jan 2004

Li Qing-Lin, Kim Hye-Ryeon, Kim Wun-Jae, Choi Joong-Kook, Lee Yong Hee, Kim Hwan-Mook, Li Long Shan, Kim Hoguen, Chang Joon, Ito Yoshiaki, Youl Lee Kwang, Bae Suk-Chul

Abstract excerpt

RUNX family transcription factors are integral components of TGF-beta signaling pathways and have been implicated in cell cycle regulation, differentiation, apoptosis, and malignant transformation. It was noted previously that allele loss and loss of expression of RUNX3 are causally involved in gastric carcinogenesis. Our results demonstrate that RUNX3 is inactivated by aberrant DNA methylation in approximately...

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Share to Core Binding Factor Alpha 3 Subunit
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Methylation

Share to DNA, Neoplasm

Share to Gene Expression Regulation, Neoplastic

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Share to Lung Neoplasms

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Source

Identifiers

PMID: 14715269
DOI: 10.1016/j.bbrc.2003.12.079

Genes

RUNX3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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Transcriptional silencing of the RUNX3 gene by CpG hypermethylation is associated with lung cancer.PMID 14715269Read ↗

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