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Article

A functional polymorphism in the DNA methyltransferase-3A promoter modifies the susceptibility in gastric cancer but not in esophageal carcinoma.

BMC medicine - 3 Feb 2010

Fan Hong, Liu Dongsheng, Qiu Xuemei, Qiao Fengchang, Wu Qingxiang, Su Xianwei, Zhang Feng, Song Yunwei, Zhao Zhujiang, Xie Wei

Abstract excerpt

BACKGROUND: DNA-methyltransferase (DNMT)-3A plays an important role in the development of embryogenesis and the generation of aberrant methylation in carcinogenesis. The aim of this study was to investigate the role of a DNMT3A promoter genetic variant on its transcriptional activity and to evaluate the association between DNMT3A gene polymorphism and the susceptibility to gastric cancer (GC) and oesophagus...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 20128888
DOI: 10.1186/1741-7015-8-12
PMCID: PMC2829483

Provenance

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Source receipt: pubmed, retrieved 7 Sept 2026.

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