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Article

Hypermethylation of RUNX3 but not WIF1 gene and its association with stage and nodal status of tongue cancers

13 Jul 2011

Abstract excerpt

OBJECTIVES: Recent studies indicate various molecular abnormalities in oral squamous cell carcinomas (OSCC), including DNA methylation of tumor-associated genes. Although promoter hypermethylation of Wnt pathway antagonists RUNX3 (Runt-related transcription factor 3) and Wnt inhibitory factor 1 (WIF1) has been identified as a common event in a number of carcinomas, methylation status and the role of RUNX3 as a...

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PMID: 21819494
DOI: 10.1111/j.1601-0825.2011.01838.x

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