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Article

RUNX3 downregulation in human lung adenocarcinoma is independent of p53, EGFR or KRAS status.

Pathology oncology research : POR - 1 Oct 2012

Omar Mohd Feroz Mohd, Ito Kosei, Nga Min En, Soo Ross, Peh Bee Keow, Ismail Tuty Muliana, Thakkar Bhavin, Soong Richie, Ito Yoshiaki, Salto-Tellez Manuel

Abstract excerpt

RUNX3 aberrations play a pivotal role in the oncogenesis of breast, gastric, colon, skin and lung tissues. The aim of this study was to characterize further the expression of RUNX3 in lung cancers. To achieve this, a lung cancer tissue microarray (TMA), frozen lung cancer tissues and lung cell lines were examined for RUNX3 expression by immunohistochemistry, while the TMA was also examined for EGFR and p53...

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Source

Identifiers

PMID: 22729835
DOI: 10.1007/s12253-011-9485-5

Genes

RUNX3
EGFR
KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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