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Elevated expression of RUNX3 co-expressing with EZH2 in esophageal cancer patients from India

10 Sept 2020

Abstract excerpt

Abstract Background Runt related transcription factor3 (RUNX3) is considered as a tumor suppressor gene (TSG) that functions through the TGF-β dependent apoptosis. Promoter methylation of the CpG islands of RUNX3 and overexpression of enhancer of zeste homolog 2 (EZH2) has been suggested to downregulate RUNX3 in cancer. Methods Here, we studied the expression of RUNX3 and EZH2 in 58 esophageal tumors along with...

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PMID: 32943993
DOI: 10.1186/s12935-020-01534-y

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