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Article

Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer.

Cancer research - 15 Oct 2007

Sauna Zuben E, Kimchi-Sarfaty Chava, Ambudkar Suresh V, Gottesman Michael M

Abstract excerpt

Polymorphisms in the human genome contribute to wide variations in how individuals respond to medications, either by changing the pharmacokinetics of drugs or by altering the cellular response to therapeutic agents. The goal of the emerging discipline of pharmacogenomics is to personalize therapy based on an individual's genotype. Due to the relatively large frequency of single-nucleotide polymorphisms (SNP) in...

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Source

Identifiers

PMID: 17942888
DOI: 10.1158/0008-5472.CAN-07-2377

Genes

ABCB1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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