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Article

Motif module map reveals enforcement of aging by continual NF-kappaB activity.

Genes & development - 15 Dec 2007

Adler Adam S, Sinha Saurabh, Kawahara Tiara L A, Zhang Jennifer Y, Segal Eran, Chang Howard Y

Abstract excerpt

Aging is characterized by specific alterations in gene expression, but their underlying mechanisms and functional consequences are not well understood. Here we develop a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tissues and organisms. Integrated analysis of 365 microarrays spanning nine tissue types predicted fourteen motifs as...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18055696
DOI: 10.1101/gad.1588507
PMCID: PMC2113026

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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