Article
Methylation of the UNC5C gene is frequently detected in hepatocellular carcinoma.
Hepato-gastroenterology - 1 Jan 2000
Hibi Kenji, Sakuraba Kazuma, Shirahata Atsushi, Goto Tetsuhiro, Saito Mitsuo, Ishibashi Kazuyoshi, Kigawa Gaku, Nemoto Hiroshi, Sanada Yutaka
Abstract excerpt
BACKGROUND/AIMS: Recently, we detected that UNC5C expression was downregulated in colon and gastric cancer. METHODOLOGY: In the present study, the methylation status of the UNC5C gene was examined in primary carcinomas and the corresponding normal tissues derived from 42 patients with HCC. RESULTS: Methylation of the UNC5C gene was detected in 11 out of the 42 (26%) HCCs, suggesting that the methylation of UNC5C...
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