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Article

Hypermethylated Promoters of Genes UNC5D and KCNA1 as Potential Novel Diagnostic Biomarkers in Colorectal Cancer

1 Oct 2020

Abstract excerpt

Aim: Identification of aberrant hypermethylation in promoter regions of candidate genes to discover potential biomarkers for colorectal cancer. Materials & Methods: Genes BMP2, IRF4, KCNA1, LRRC7, NRG3, SLC27A6 and UNC5D were pre-selected in a bioinformatics study for their hypermethylation status in colorectal cancer. Methylation analysis was performed on 202 cancer tissue specimens to validate candidate genes....

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PMID: 33078631
DOI: 10.2217/epi-2020-0118

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