Article
Frequent inactivation of axon guidance molecule RGMA in human colon cancer through genetic and epigenetic mechanisms.
Gastroenterology - 1 Jul 2009
Li Vivian S W, Yuen Siu Tsan, Chan Tsun Leung, Yan Helen H N, Law Wai Lun, Yeung Bonnie H Y, Chan Annie S Y, Tsui Wai Yin, So Samuel, Chen Xin, Leung Suet Yi
Abstract excerpt
BACKGROUND & AIMS: Repulsive guidance molecule member A (RGMA) is a glycosylphosphatidylinositol-anchored glycoprotein and axon guidance molecule that signals through its receptor, neogenin (NEO1), a homologue of the deleted-in-colorectal cancer (DCC) gene. RGMA also functions as a bone morphogenetic protein (BMP) coreceptor. We studied the potential roles of RGMA and NEO1 in colorectal cancer (CRC) pathogenesis....
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