Article
Variants in the netrin-1 receptor UNC5C prevent apoptosis and increase risk of familial colorectal cancer.
Gastroenterology - 1 Dec 2011
Coissieux Marie-May, Tomsic Jerneja, Castets Marie, Hampel Heather, Tuupanen Sari, Andrieu Nadine, Comeras Ilene, Drouet Youenn, Lasset Christine, Liyanarachchi Sandya, Mazelin Laetitia, Puisieux Alain, Saurin Jean-Christophe, Scoazec Jean-Yves, Wang Qing, Aaltonen Lauri, Tanner Stephan M, de la Chapelle Albert, Bernet Agnès, Mehlen Patrick
Abstract excerpt
BACKGROUND & AIMS: Expression of the netrin-1 dependence receptor UNC5C is reduced in many colorectal tumors; mice with the UNC5C mutations have increased progression of intestinal tumors. We investigated whether specific variants in UNC5C increase risk of colorectal cancer (CRC). METHODS: We analyzed the sequence of UNC5C in blood samples from 1801 patients with CRC and 4152 controls from 3 cohorts (France,...
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