Article
UDP-glucuronosyltransferase 1A7 polymorphisms are associated with liver cirrhosis.
Biochemical and biophysical research communications - 15 Feb 2008
Tang Kung-Sheng, Lee Chuan-Mo, Teng Hsiu-Chen, Huang May-Jen, Huang Ching-Shan
Abstract excerpt
Variations in the UDP-glucuronosyltransferase (UGT) 1A7 gene have been found to be related to the development of hepatocellular carcinoma (HCC). Since the pathogenesis of liver cirrhosis is not dissimilar to that of HCC, we hypothesized that UGT1A7 genetic polymorphisms may be associated with liver cirrhosis. PCR-restriction fragment length polymorphism was utilized to determine UGT for 1A7 genotypes for the 159...
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