Article
UDP-glucuronosyltransferase UGT1A7 genetic polymorphisms in hepatocellular carcinoma: a differential impact according to seropositivity of HBV or HCV markers?
BMC cancer - 19 Nov 2007
Stücker I, Loriot M A, N'koutchou G, Cénée S, Bodin L, Mulot C, Gelu-Simeon M, Pelletier L, Bronowicki J P, Degos F, Beaune P, Laurent-Puig P, Hémon D, Trinchet J C, Pelletier G
Abstract excerpt
BACKGROUND: We conducted a case-control study to evaluate the role of UDP-glucuronosyltransferase 1A7 (UGT1A7) polymorphisms in the onset of hepatocellular carcinoma (HCC). METHODS: The study included 165 patients with HCC, 134 with cirrhosis and 142 controls without liver disease, matched for age and hospital. All were men younger than 75 years. HCC and cirrhosis patients were stratified according to time since...
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