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Article

UGT1A polymorphisms as genetic biomarkers for hepatocellular carcinoma risk in Caucasian population.

Liver international : official journal of the International Association for the Study of the Liver - 1 Sept 2017

De Mattia Elena, Cecchin Erika, Polesel Jerry, Lupo Francesco, Tiribelli Claudio, Crovatto Marina, Buonadonna Angela, Toffoli Giuseppe

Abstract excerpt

BACKGROUND & AIMS: The definition of new biomarkers of hepatocellular carcinoma (HCC) risk, especially in high-risk HBV/HCV-positive population, is urgently needed to improve HCC clinical management. This study focused on variants of UDP-glucuronosyltransferase 1A (UGT1A) enzymes that catalyse the reaction of glucuronidation, one of the most important chemical defence pathway of the body. The aim of this study...

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PMID: 28294511
DOI: 10.1111/liv.13411

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