Article
Predisposing genetic factors for diabetic polyneuropathy in patients with type 1 diabetes: a population-based case-control study.
Acta diabetologica - 1 Dec 2003
Strokov I A, Bursa T R, Drepa O I, Zotova E V, Nosikov V V, Ametov A S
Abstract excerpt
Oxidative stress plays a key role in the development of microvascular complications of diabetes mellitus (DM). Antioxidant enzymes protect against the rapid onset of diabetic polyneuropathy (DPN) by reducing oxidative stress. Genetic variations that affect activity or expression levels of the antioxidant enzymes may therefore be associated with susceptibility to DPN. We examined polymorphic markers Ala(-9)Val in...
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