Article
Association of PARP-1, NF-κB, NF-κBIA and IL-6, IL-1β and TNF-α with Graves Disease and Graves Ophthalmopathy.
Gene - 1 Sept 2014
Niyazoglu Mutlu, Baykara Onur, Koc Arzuhan, Aydoğdu Pinar, Onaran Ilhan, Dellal Fatma Dilek, Tasan Ertuğrul, Sultuybek Gönül Kanigur
Abstract excerpt
BACKGROUND: Graves Disease (GD) is an autoimmune disorder affected by an interaction of multiple genes such as Nuclear Factor-κB (NF-κB), Nuclear Factor-κB Inhibitor (NF-κBIA), Poly (ADP-ribose) polymerase-1 (PARP-1) and cytokines like Interleukin-1β (IL-1β), Interleukin-6 (IL-6) and Tumor Necrosis Factor-α (TNF-α) and mostly accompanied by an ocular disorder, Graves Ophthalmopathy (GO). We hypothesize that there...
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