Article
Type II pneumocyte-restricted green fluorescent protein expression after lentiviral transduction of lung epithelial cells.
Human gene therapy - 1 Jan 2008
Wunderlich Stephanie, Gruh Ina, Winkler Monica E, Beier Jennifer, Radtke Kerstin, Schmiedl Andreas, Groos Stephanie, Haverich Axel, Martin Ulrich
Abstract excerpt
Type II alveolar epithelial (AT2) cell-specific reporter expression has been highly useful in the study of embryology and alveolar regeneration in transgenic mice. Technologies enabling efficient gene transfer and cell type-restricted transgene expression in AT2 cells would allow for correction of AT2 cell-based diseases such as genetic surfactant deficiencies. Moreover, such approaches are urgently required to...
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