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Article

Differentiation of mouse induced pluripotent stem cells into alveolar epithelial cells in vitro for use in vivo.

Stem cells translational medicine - 1 Jun 2014

Zhou Qiliang, Ye Xulu, Sun Ruowen, Matsumoto Yoshifumi, Moriyama Masato, Asano Yoshiya, Ajioka Yoichi, Saijo Yasuo

Abstract excerpt

Alveolar epithelial cells (AECs) differentiated from induced pluripotent stem cells (iPSCs) represent new opportunities in lung tissue engineering and cell therapy. In this study, we modified a two-step protocol for embryonic stem cells that resulted in a yield of ∼9% surfactant protein C (SPC)(+) alveolar epithelial type II (AEC II) cells from mouse iPSCs in a 12-day period. The differentiated iPSCs showed...

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Identifiers

PMID: 24763685
DOI: 10.5966/sctm.2013-0142
PMCID: PMC4039451

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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