Article

Lentiviral vectors transduce lung stem cells without disrupting plasticity

2020-10-19

Abstract excerpt

Life-long expression of a gene therapy agent likely requires targeting stem cells. Here we ask the question: does viral vector transduction or ectopic expression of a therapeutic transgene preclude airway stem cell function? We used a lentiviral vector containing a GFP or cystic fibrosis transmembrane conductance regulator ( CFTR ) transgene to transduce primary airway basal cells from human cystic fibrosis (CF)...

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Literature Corpus work: a81314e5-2628-5583-9da3-3c2e534bbb88
DOI: 10.1101/2020.10.19.345611

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