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Heterogeneity in Human Induced Pluripotent Stem Cell–derived Alveolar Epithelial Type II Cells Revealed with ABCA3/SFTPC Reporters

8 Jun 2021

Abstract excerpt

Abstract Alveolar epithelial type 2 cells (AEC2s), the facultative progenitors of lung alveoli, are typically identified through the use of the canonical markers, SFTPC and ABCA3. Self-renewing AEC2-like cells have been generated from human induced pluripotent stem cells (iPSCs) through the use of knock-in SFTPC fluorochrome reporters. However, developmentally, SFTPC expression onset begins in the fetal distal...

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Identifiers

PMID: 34101541
DOI: 10.1165/rcmb.2020-0259oc

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