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Article

Humanized L184Q Mutated Surfactant Protein C Gene Alters Alveolar Type 2 Epithelial Cell Fate.

International journal of molecular sciences - 9 Aug 2024

Jain Krishan G, Liu Yang, Zhao Runzhen, Muire Preeti J, Zhang Jiwang, Zang Qun Sophia, Ji Hong-Long

Abstract excerpt

Alveolar type 2 epithelial (AT2) cells synthesize surfactant protein C (SPC) and repair an injured alveolar epithelium. A mutated surfactant protein C gene (SftpcL184Q, Gene ID: 6440) in newborns has been associated with respiratory distress syndrome and pulmonary fibrosis. However, the underlying mechanisms causing Sftpc gene mutations to regulate AT2 lineage remain unclear. We utilized three-dimensional (3D)...

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Identifiers

PMID: 39201410
DOI: 10.3390/ijms25168723
PMCID: PMC11354303

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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