Article
The inhibition of polo kinase by matrimony maintains G2 arrest in the meiotic cell cycle.
PLoS biology - 1 Dec 2007
Xiang Youbin, Takeo Satomi, Florens Laurence, Hughes Stacie E, Huo Li-Jun, Gilliland William D, Swanson Selene K, Teeter Kathy, Schwartz Joel W, Washburn Michael P, Jaspersen Sue L, Hawley R Scott
Abstract excerpt
Many meiotic systems in female animals include a lengthy arrest in G2 that separates the end of pachytene from nuclear envelope breakdown (NEB). However, the mechanisms by which a meiotic cell can arrest for long periods of time (decades in human females) have remained a mystery. The Drosophila Matrimony (Mtrm) protein is expressed from the end of pachytene until the completion of meiosis I. Loss-of-function mtrm...
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