Article
Lack of association of single nucleotide polymorphism in LRCH1 with knee osteoarthritis susceptibility.
Journal of human genetics - 1 Jan 2008
Jiang Qing, Shi Dongquan, Nakajima Masahiro, Dai Jin, Wei Jia, Malizos Konstantinos N, Qin Jianghui, Miyamoto Yoshinari, Kamatani Naoyuki, Liu Baorui, Tsezou Aspasia, Nakamura Takahiro, Ikegawa Shiro
Abstract excerpt
A genetic association of knee osteoarthritis (OA) and a C/T transition single nucleotide polymorphism (SNP) (rs912428) located in intron 1 of the LRCH1 gene has recently been reported in European Caucasians; however, the results are inconsistent. Our objective was to evaluate the association in different knee OA populations. Three case-control association studies were conducted in Han Chinese, Japanese, and Greek...
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