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Article

Association between a variation in LRCH1 and knee osteoarthritis: a genome-wide single-nucleotide polymorphism association study using DNA pooling.

Arthritis and rheumatism - 1 Feb 2006

Spector Tim D, Reneland Richard H, Mah Steven, Valdes Ana M, Hart Deborah J, Kammerer Stefan, Langdown Maria, Hoyal Carolyn R, Atienza Josephine, Doherty Michael, Rahman Proton, Nelson Matthew R, Braun Andreas

Abstract excerpt

OBJECTIVE: To perform a large-scale association analysis of single-nucleotide polymorphisms (SNPs) in patients with radiographically defined osteoarthritis (OA) of the knee. METHODS: We examined >25,000 SNPs located within approximately 14,000 genes for associations with radiographically defined knee OA, using polymerase chain reaction and MassExtend amplification techniques. Allele frequencies were estimated...

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PMID: 16447229
DOI: 10.1002/art.21624

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

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