Article
Lack of association between the CALM1 core promoter polymorphism (-16C/T) and susceptibility to knee osteoarthritis in a Chinese Han population.
BMC medical genetics - 22 Oct 2008
Shi Dongquan, Ni Haijian, Dai Jin, Qin Jianghui, Xu Yong, Zhu Lunqing, Yao Chen, Shao Zhenxing, Chen Dongyang, Xu Zhihong, Yi Long, Ikegawa Shiro, Jiang Qing
Abstract excerpt
BACKGROUND: CALM1 gene encodes calmodulin (CaM), an important and ubiquitous eukaryotic Ca2+-binding protein. Several studies have indicated that a deficient CaM function is likely to be involved in the pathogenesis of osteoarthritis (OA). Using a convincing genome-wide association study, a Japan...
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