Article
Association of -319 C/T and +49 A/G polymorphisms of CTLA-4 gene in patients with hepatitis C virus infection.
Medicina clinica - 13 Apr 2018
Enciso-Vargas Moisés, Ruíz-Madrigal Bertha, Muñoz-Valle José Francisco, Morales-Balderas Omar Yair, Hernández-Nazara Zamira Helena, Martínez-López Erika, Dávalos-Cobian Carlos, Padilla-Gutiérrez Jorge Ramón, Torres-Baranda José Rodrigo, Domínguez-Rosales José Alfredo, Maldonado-González Montserrat
Abstract excerpt
INTRODUCTION AND OBJECTIVE: Molecular changes in the CTLA-4 gene can modify the ability to control T lymphocyte proliferation, and promote the persistence or elimination of the hepatitis C virus (HCV). We aimed to investigate the frequency and association of -319 C/T and +49 A/G polymorphism in the CTLA-4 gene in patients infected with HCV. METHODS: The CTLA-4 gene polymorphisms (-319 C/T in the promoter region,...
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