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Article

CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.

Journal of cell science - 15 Jan 2010

Yoshida Kazumasa, Sugimoto Nozomi, Iwahori Satoko, Yugawa Takashi, Narisawa-Saito Mako, Kiyono Tohru, Fujita Masatoshi

Abstract excerpt

CDC6, a replication licensing protein, is partially exported to the cytoplasm in human cells through phosphorylation by Cdk during S phase, but a significant proportion remains in the nucleus. We report here that human CDC6 physically interacts with ATR, a crucial checkpoint kinase, in a manner t...

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Source

Identifiers

PMID: 20048340
DOI: 10.1242/jcs.058693

Genes

CDC6
ATR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20048340-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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CDC6 interaction with ATR regulates activation of a replication checkpoint in higher eukaryotic cells.PMID 20048340Read ↗

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Mutation of cyclin/cdk phosphorylation sites in HsCdc6 disrupts a late step in initiation of DNA replication in human cells.Semantic proximity Read ↗

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