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Article

Cdc6 as a novel target in cancer: Oncogenic potential, senescence and subcellular localisation.

International journal of cancer - 15 Sept 2020

Lim Nicholas, Townsend Paul A

Abstract excerpt

Cdc6 is a key replication licencing factor with a pivotal role in regulating the process of DNA replication, rendering it an important investigatory focus in tumourigenesis. Indeed, Cdc6 overexpression has been found to be a feature in certain tumours and has been associated as an early event in malignancies. With a focus on pancreatic cancer, there are evidence of its convergence in downstream pathways...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 32010971
DOI: 10.1002/ijc.32900
PMCID: PMC7496346

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