Article

In-silico analysis of nsSNPs in human CYP3A4/5 and their effects on drug-enzymes interactions of FDA-approved COVID-19 antiviral drugs: A pharmacogenetic study

2024-02-13

Abstract excerpt

<title>Abstract</title> <p>Single nucleotide polymorphisms (SNPs) represent the prevailing form of genetic variations observed in the human population. Such variations could alter the encoded enzymes’ activities. CYP3A4/5 enzymes have a pivotal role in metabolising drugs, notably antivirals against SARS-CoV-2. In this work we computationally investigated antiviral-enzyme interactions of CYP3A4/5 genetic variants....

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Literature Corpus work: 73d44543-f4e2-5893-a723-79e6c3f5d73c
DOI: 10.21203/rs.3.rs-3910067/v1

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