Article
CT60 A/G marker of the 3'-UTR of the CTLA4 gene and liver transplant.
Transplant immunology - 1 Jan 2008
Muro Manuel, Rojas Gloria, Botella Carmen, Miras Manuel, Campillo José A, Minguela Alfredo, Sánchez-Bueno Francisco, Bermejo Juan, Ramírez Pablo, Alvarez-López María R
Abstract excerpt
The CTLA4 molecule is a homolog for CD28, and both molecules and their common ligands (CD80 and CD86) constitute the B7/CD28-CTLA4 co-stimulatory pathway for T cells activation. The CTLA4-ligand interaction has an inhibitory effect on T cell activation and might contribute to peripheral tolerance. A recently described CT60 A/G polymorphism affects the production of soluble CTLA4 and is strongly associated with...
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